Bovine Spongiform Encephalopathy

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All mammals have prion proteins as the following table shows:

Disease abbreviation Natural host Prion Abnormal PrP Term Alternate PrP Term
scrapie sheep & goats Scrapie ShePrPSc ShePrPSc"
transmissible mink prionencephalopathy (TME) mink TME MkPrPSc MkPrPScTME
chronic wasting disease (CWD) mule deer & elk CWD prion MDePrPSc MDePrPCWD
bovine spongiform encephalopathy (BSE) cattle BSE prion BovPrPSc BovPrPBSE
feline spongiform encephalopathy (FSE) cats FSE prion FePrPSc FePrPFSE
exotic ungulate encephalopathy (EUE) nyala & greater kudu EUE prion NyaPrPSc NyaPrPEUE
kuru humans Kuru prion HuPrPSc HuPrPKu
Creutzfeldt-Jakob disease (CJD) humans CJD prion HuPrPSc HuPrPCJD
Gerstmann-Straussler-Scheinker syndrome (GSS) humans GSS prion HuPrPSc HuPrPGSS
fatal familial insomnia (FFI) humans FFI prion HuPrPSc HuPrPFFI


Table 1: The Spongiform Encephalopathies

As can be seen from the following diagram, comparing a mouse and a hamster prion, prions from different species are very similar to each other.

The experience of kuru and CJD transmitted via human growth hormone injections demonstrates how it is possible for one human being to be infected by another human being. Although, the actual infection process is still a matter for research.

For one of the central hypotheses of BSE transmission to humans to be true, it is necessary for animal prions, particularly bovine ones, to have the same or similar effect to human ones.


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